Product Description
Georgetown University, Washington, D.C. Text on the science of gene therapy, for non-specialists, lay-level readers, and medical ethicists. Presents the ethical and public policy issues concerning interventions in human heredity. ... Read more

Customer Reviews (1)

Solid and compelling
Walters and Palmer present here a solid argument regarding the impending technology of human gene therapy.They walk through the science carefully, but the core of the book is on the development of criteria for when trials in gene therapy would be acceptable. While this reviewer does not agree with every stand they take, the book will be a classic in the ethics of gene therapy because of its careful argument and thorough analysis. ... Read more

Product Description
Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy though still in its infancy remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ("vector") to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession.

This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system. Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy. ... Read more

Product Description
National Institutes of Health, Bethesda, Maryland. Research on the molecular genetics of cardiovascular disease and new or developing gene therapies. 50 contributors, 47 U.S. ... Read more

Product Description
Brown Univ., Providence, RI. Presents detailed methods and protocols covering a comprehensive range of technologies and techniques used by leaders in the field of gene therapy. Previous edition: c1997. DNLM: Gene Therapy--methods. ... Read more

Customer Reviews (2)

A Top Diabetes Medical Reference
Guide to Complementary Treatment for Diabetes
by Gene Bruno, MS, MHS Square One Publishers

Reviewed by Dr. Joseph S. Maresca
______________________________________________________

The author describes various strategies for reducing the
harmful effects of diabetes. A raw food vegan diet may benefit
diabetics since insulin requirements are reduced.
There are additional benefits with a reduction in the C-reactive
protein which is monitored very closely by cardiologists.
Vit B supplements may be helpful to diabetics in addition
to others .

Increased blood glucose levels are associated with neuropathy,
increased blood pressure, increased cholesterol levels and other
implications. Normal blood glucose levels are
associated with reduced diabetic complications.The endocrinologist
is concerned about A1C levels above 7. Examples of low glycemic
foods are bean sprouts, grapefruit, peanuts, pizza and low fat yogurt.
An increased glycemic index is associated with
white rice, popcorn, table sugar and baked potato.
Omega 3 fats are associated with fewer heart attacks.

Various diets are explained in this book. i. e. the Mediterranean
Diet of fruits, veggies, whole grains, beans, nuts, seeds and
olive oil.Dairy, eggs, fish and poultry may be
consumed in moderate amounts. Consumption of organic
foods is encouraged. I can attest to these benefits from
personal experience. Generally speaking, processed foods are out.

Extensive nutrients are recommended for diabetics. B complex
vitamins are helpful for energy metabolism.Calcium benefits
the bones, teeth and blood clotting. Magnesium is helpful
for muscles and nerves. Chromium is necessary for glucose
tolerance. Copper is helpful for the nerve fibers and
red blood cells. Iodine is helpful for the thyroid.
Water soluble cinnamon is associated with reduced fasting
blood sugar levels. I've taken these nutrients and found them
to be helpful in normalizing blood sugar and reducing the
symptoms of pre-diabetics.

Gymnema extract at 400 milligrams is associated with reduced
blood glucose and A1C levels. Milk thistle is helpful for
the liver. 150 minutes of exercise per week reduces diabetes
risks by 20% to 30%.Acetyl L. Carnitine transports fats
into muscle cells where energy is burned.Magnet therapy is
associated with decreased numbness and tingling in the
feet.I've had a magnetic mattress and magnets sewn
into the clothing for years. Both of these steps have helped to
reduce the classic symptoms of pre-diabetics.
Coenzyme Q10 helps with free radical savaging.

The book has a very extensive set of references which aids in
the credibility of statements made by the author.
Examples of the references are from JAMA, Arthritis Rheumatology,
Swiss Medical Weekly, Free Radical Biology Med, Diabetes Care
and the American Family Physician. Overall, the presentation
is excellent and priced reasonably.

Great Primer
Mr. Bruno has written a simple, but concise, overview of integrative approaches to managing Diabetes.His research is evidence based and much of what he discusses lends itself to adjunctive therapies.I suggest that diabetics discuss these approaches with their healthcare providers.I will recommend it to my diabetic patients.
Art Presser, Pharm.D.
... Read more

Product Description

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Product Description

• Summarises and reviews the important field of genetic therapy with respect to the latest immunological advances in the lab and clinic
• Unique treatment of immunology and immunotherapy in gene - approached from a vector and target organ point of view rather than from the perspective a specific diseases
• Broad appeal - applicable for  immunology and genetics / gene therapy, recombinant DNA studies, transplantation, virology, cancer research and tumor research

Product Description
1 D.V. Schaffer, W. Zhou: Gene Therapy as Future Human Therapeutics.- 2 J. Heidel, S. Mishra, M.E. Davis: Molecular Conjugates.- 3 M. Manthorpe, P. Hobart, G. Hermanson, M. Ferrari, A. Geall, B. Goff, A. Rolland: Plasmid Vaccines and Therapeutics: From Design to Applications.- 4 S.R. Little, R. Langer: Non-Viral Delivery of Cancer Genetic Vaccines.- 5 J.C. Grieger, R.J. Samulski: Adeno-Associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications.- 6 J.H. Yu, D.V. Schaffer: Advanced Targeting Strategies for Murine Retroviral and Adeno-Associated Viral Vectors.- 7 N. Loewen, E.M. Poeschla: Lentiviral Vectors.- 8 N.E. Altaras, J.G. Aunins, R.K. Evans, A. Kamen, J.O. Konz, J.J. Wolf: Production and Formulation of Adenovirus Vectors.- ... Read more

Product Description
Treatment is the heart of medicine. For patients, the main aim of visiting a physician is to get the best therapy. Therapy has a long history. Advanced biotechnology helps improve medical treatment. Apart from the classical treatments, there are many new emerging means of medical treatment. In this book, the concept of new therapeutic channels, cell, gene and molecular concepts is developed. Interesting details on concepts for these modern therapies can be found in this book. ... Read more

Product Description
Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression.

New Topics Covered in this Edition:

This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies. ... Read more

Product Description

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Product Description
Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells.
Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers.
This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience. ... Read more

Product Description

This is a landmark introduction to the facts and hopes of gene therapy: an exciting, albeit controversial, technique that could bring about a new age in medical treatment. Modern medicine has had relatively little to offer children with disorders such as thalassemia and severe combined immune deficiency. Many of these young patients still face repeated hospitalizations and, often, an early death. In gene therapy, a child with life-threatening genetic disease caused by a defect in a single gene will he treated with the gene's normal counterpart. Successful development of somatic cell gene therapy is potentially the most effective new therapeutic approach to helping these children lead normal lives.

With unusual clarity of style, Eve K. Nichols (author of theacclaimed Mobilizing against AIDS) explores the potential for gene therapy and identifies those who are candidates for it. She reviews methods for diagnosing genetic diseases and evaluates current forms of therapy. Having provided a biomedical background for understanding somatic cell gene therapy, Nichols takes a thoughtful look at complex and sensitive issues surrounding ethical, economic, and policy aspects of manipulating human genes. A straightforward analysis of the current limitations and future potential of gene therapy concludes her broadly accessible account.

This book is is derived from the annual session of the prestigious Institute of Medicine. Distinguished participants in this meeting, such as Leon Rosenberg (Dean of the Yale Medical School), Philip Leder (Harvard Medical School), David Martin (Vice President, Genentech, Inc.), James Wyngaarden (Director of the National Institutes of Health), and LeRoy Walters (Director of the Center for Bioethics, Georgetown University),have contributed expert perspectives that will establish this book as a standard of excellence for future studies. A preface by Frank Press, President of the National Academy of Sciences, provides an insightful overview of this promising new therapy.

Product Description
This title explains what gene therapy is, how genes are delivered and how they are targeted. It discusses recent gene therapy trials, future applications and considers the ethical and safety issues surrounding gene therapy. Understanding Gene Therapy is a ... Read more

Customer Reviews (1)

Fantastic book on understanding gene therapy
This was a great book, and gave the truth about the pros and cons of gene therapy and the progress that has been achieved.This book is appropriate for undergrads with a strong science background, medical students, science graduate students, and physicians and researchers and would be very important reading on this quickly emerging field.Included are some nice diagrams and some up-to-date key references in the field that will encompass the future of medicine. ... Read more

Product Description
Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. Volume 40, GeneTherapy, features important new research on gene transfers and therapy in the herpes simplex virus, anti-tumor immunity, steroid receptors, cystic fibroses, and more.

Key Features
* It provides an excellent overview on a series of topics on gene therapy for the serious investigator ... Read more

Product Description
W. Norton. Offers a fundamental understanding of the narrative approach to therapy and illustrates some of the potential applications of the technique. Based upon both narrative and social construction metaphors and the concepts of David Epston and Michael White. For therapists. ... Read more

Customer Reviews (12)

Sadly, great truthiness
Reviewer Micheal Kaan states that, "Despite its claims to miraculous and rapid cures, it turns out from research that NT is--surprise--as effective as any other kind of therapy."

Let's review for a moment the effectiveness of other kinds of therapy. In 1951, for example, Powers and Witmer studied 650 high-risk boys. Half were counseled and sent to YMCA. After 5 years, all of the therapists felt most boys had "benefited substantially." Moreover, the boys agreed and said the counseling had given them insight and kept them out of trouble. Yet, a 30-year follow up study in 1981 found the "helped" boys committed more serious crimes and were more affected by alcoholism, mental illness such as depression, and lower job satisfaction than those left alone. For another example, research published in the American Journal of Psychiatry in 1967 followed 301 people who had been arrested for "public drunkenness" in San Diego and were randomly assigned to three groups: no treatment, referral to professional counseling, or Alcoholics Anonymous and the group with the greatest continued drinking (in fact, more than before treatment) and the most re-arrests were the individuals sentenced to AA while the most successful at staying out of jail were those in the control group receiving no treatment at all. Finally, Elliot (1998) reviewed 500 violence prevention programs and all but three (receiving the least funding) failed to address any known risk factors and likely only made things worse. Which mode of treatment is most effective? They are all equally poor (some put the number at only 5% effective). Why?

For at least four centuries, what is today called Murphy's Law was known as Sod's Law. Sod's Law stated that if anything can be done wrong that some sod (or in these cases, therapist) will do it wrong. Alas, Sod's Law (or Murphy's) has become its own worst victim in a post-modern age where we get to simply blame bad luck rather than poor efforts (which actually came out of a religion created by a Larry Niven science fiction story - a useful comparison to the popular religion of this field). This text is supposed to be introducing us to techniques to address this very problem (which it starts out doing). Unfortunately, the very social contructionism that should be utilized to uncover the ways in which individuals participate in creating their perceived but inaccurate social reality is here only watered down into a sappy, vague, and unsupported composition making the potential solution only another victim to itself that is further tainted by personal bias and arrogance that (like all of the other mistaken but popular therapies) can be easily mistaken as professionally academic. In avoiding traditional "medical model" language simply because it's common overuse has more often pathologized patients (rather than only editing out objectifying speech), this field is throwing the baby out with the bathwater and ends up being no better or worse (again, as Micheal Kaan points out). In the same way, one can easily explain the positive reviews of this book by simply looking under Colberianism for the social constructionist concept of truthiness.

My review is certainly clouded (the book deserves at least two stars for being better than average for books on the subject) by my overwhelming disappointment in the entire therapy industry and the Narrative Movement in particular (potentially a silver bullet for conflict resolution). For instance, people often confuse the story of when Moses came to the King of Egypt with ten plagues and dire warnings as an attempt to provide a narrative for the King to change but God repeats again and again that He had a seemingly unfair freezing of such change in the King. This is because the narrative was really to provide an externalization of sin for the Jews by a literal use of the third person... helping them accept how they had become alienated from their own values, hopes, and commitments by being part of an socio-political "mob" for a self-destructive reality. This greater articulation through externalizing language and relevant audiences provided not only the classic narrative "breaking of the ice" but also a step-by-step action plan that built not only a subjective reference to understanding but also an objective neutral one to allow an unfreezing of inaccurate political rightness and slow refreezing of a healthier measurable worldview. Too often such references for the need of specific measurable objectivity seem to be wholly refused by modern narrative practitioners where they end up only being their own worst enemies.

The U.S. Supreme Court ruled Creation Science is not a "science" specifically due to its refusal to subject itself to objective review. Yet, we too often provide just such privileges to "real" scientists. Just as no creation "scientist" will ever yell at another in his/her field, "Your overuse of poorly defined jargon and under use of randomized trials or comparison groups invalidates any conclusion" - the Narrative Movement (or is that Ministry) seems sadly just another cult of mutual admiration. One must maintain the use of neutral language and never be persuaded by the "dark side" of popular "new age" postmodern relativism. Without enough supporting evidence from a position of objective neutrality, this otherwise well written text becomes just another emperor with no clothes. And, the prevalent need to view males negatively is another overwhelmingly disappointing pointer to personal agendas that leaves the resulting politicized advice hypocritical and counterproductive. I say, "Boo!"

Extremely helpful...
As a counseling psychology student, I found this book to be incredibly useful in understanding the foundations of Narrative Therapy. This bookoffers a lot in the ways of theoretical orientation and basic narrative counseling skills. A must read for counselors who wish to expand their techniques.

Great Resource for Beginning Counselors!
This is a really great resource for learning about the theoretical assumptions behind narrative therapy and how to start practicing narrative techniques.Freedman and Combs do an excellent job of bringing the material to the reader in a collaborative, non-pedantic way - perfect for the post-modern, narrative viewpoint that they are conveying.I recommend this book to anyone who is interested in learning ways of connecting in a more personal and real way with their clients' life stories and personalities.Great book!

Author Review - EXCELLENT!
Narrative Therapy by Jill Freedman & Gene Combs is perhaps one of the best theraputic books I have read. As an author and human services worker, I am always looking for titles that will help me assist client's with their needs. That said, this book is a must read for anyone who wants to work through problems such as depression, anger and societal connections. I highly recommend this book - the authors did a great job!

---
John D. Moore, MS, CADC
Author of Confusing Love with Obsession

I Like it
Please ignore the non-review of July 11, and dig deep enough to see David Epston's thoughts about the book. ... Read more

Product Description
Overviews the technology behind gene therapy and provides examples of how the approach is being used in clinical medicine to treat a variety of genetic diseases, including cancer, AIDS, cardiovascular disease and rheumatoid arthritis. For scientists and healthcare workers involved in gene therapy trials, and students. Softcover. ... Read more

Product Description
This special report provides an up-to-date overview on the gene therapy industry and contains a wealth of practical information on 105 companies. For each company, information is available on the people to contact, their contact details, a corporate history, the company's technologies and products, financial data, patents held, products in clinical trials, collaborations with other companies and selected publications from the company's scientists.

Almost 200 companies were initially considered for inclusion but just over 100 companies were finally selected as they fulfilled the necessary critieria to be classified as a 'Gene Therapy Company' defined broadly to include cell therapy companies. As part of this project, new companies were discovered that have not been reported in other publications or on the internet.

Dr Jain has spared no effort to ensure that the information is up-to-date and accurate at the time of publishing. In most instances, the information was reviewed by the companies to correct any outdated information or to add any complementary or recent information.

In addition to the detailed descriptions of each company, the data is also presented in summary tabular form so that at a glance the reader can identify collaborations within the gene therapy industry, or determine which companies are pursuing strategies involving viral, non-viral, or other approaches to gene therapy, and which diseases are being targetted. Given that much of the gene therapy research and development is currently being carried out within the industrial sector, it is important for scientists, managers, and investors to have the relevant information at their fingertips. This special report provides that information in one accurate, easy to consult and up-to-date source. ... Read more