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Endocrine disruptors are chemical compounds that, among other harmful effects, cause birth defects in humans and animals. They include DES, an anti-nausea drug used in the 1950s during pregnancy, and may be found in over 70 common chemicals ranging from pesticides to plastics. This book looks at recent developments in the area and examines screening/monitoring methods and analytical techniques. ... Read more

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There is great concern regarding the reproductive and health hazards of endocrine disruptors. Research indicates that men are experiencing declining fertility and an increased incidence of prostate cancer, while women are dealing with increased infertility, early menopause, and breast cancer. As new research reveals the previously unknown risks of these endocrine disruptors, it is imperative to update our knowledge of these controversial chemicals.

Endocrine Disruptors: Effects on Male and Female Reproductive Systems, Second Edition examines the reproductive and health hazards of endocrine-disrupting environmental chemicals from epidemiology to etiology, concluding with future directions. Divided into two sections, the first part of the book describes the effects of environmental toxicants on the female reproductive system, with an emphasis on the effects and mechanisms of their action on sex differentiation during development, fertility, and breast cancer. The second part addresses the effects of endocrine disruption on the male reproductive system, focusing on male fertility and the development of benign prostate hyperplasia (BPH) and prostate cancer.

Leading authorities contribute expert analyses and up-to-date information on a topic that has become a major concern among the scientific community and the general public. This second edition supplies the most current, critical knowledge on the real risks that endocrine disruptors pose to the population. ... Read more

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The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (the present volume, Part I) and M (Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers. ... Read more

Product Description
The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers. ... Read more

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Over the past decade, EDCs and PPCPs have become a major issue for drinking water utilities. The public, scientists, and regulators all have begun actively investigating this issue, and utilities are often tasked with addressing and communicating complex and sometime conflicting scientific data. In recent times, many utilities have been faced with difficult requests from the community regarding occurrence, treatment, and health relevance data. This report serves to provide utilities with summary data useful in addressing these requests.The objective of this project was to develop a concise review on the state of knowledge of endocrine disrupting chemicals (EDCs) and pharmaceuticals and personal care products (PPCPs) in drinking water so water utilities can communicate with customers and make internal decisions on monitoring and treatment options. The purpose of the guide was to summarize the history, analytical methods, bioassays, occurrence, health relevance, and communication issues regarding endocrine disruptors and pharmaceuticals.Literature regarding EDCs and PPCPs in water was evaluated for applicability to drinking water utilities. Suitable data was determined by publication in peer-reviewed literature, data from within the research team and funding agency, and through suggestions from the Project Advisory Committee. It was not feasible, nor particularly useful, to review every chemical that could be considered a suspected EDC or a PPCP. Therefore, a subset of chemicals was chosen that are representative of the subclasses and types of EDCs and PPCPs that are of current scientific and public interest. The wealth of data evaluated was summarized into succinct chapters that provide the key findings of the review, while providing references for those who seek detailed information. ... Read more

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In recent years, it has become evident that many chemicals present in the environment can mimic, antagonize or alter the physiological actions of endogenous hormones. These compounds have been termed endocrine disrupters (EDs) and defined as exogenous substances that cause adverse health effects in an intact organism or in its progeny, consequent to changes in endocrine function . EDs, even when present in minute amounts (part per trillion), could interfere with the synthesis, secretion, transport, metabolism, binding, action, or elimination of natural hormones responsible for homeostasis maintenance, reproduction, and developmental processes.

Currently more than 100 chemicals have been identified as EDs. Within this heterogeneous group of molecules we find: (a) synthetic chemicals used in industry, agriculture, and consumer products; (b) synthetic chemicals used as pharmaceutical drugs; and (c) natural chemicals found in human and animal food. About half of these compounds are substituted with halogen groups, mostly chlorine and bromine, and include dioxins, polychlorinated biphenyls, organochlorine pesticides, methoxychlor, dieldrin, and hexachlorocyclohexane. EDs have long environmental half-life resulting in a continue increase of their global concentration in the environment and can be detected and may concentrate at great distances from where they are produced, used or released. EDs have very low water solubility and extremely high lipid solubility, leading to their bioaccumulation in adipose tissue. Exposure to EDs can occur from a number of different sources: humans and animals can be exposed involuntarily by drinking contaminated polluted water, breathing contaminated air, ingesting food, contacting contaminated soil or even in the workplace.

Although endocrine disruption has only received high-profile attention for just over a decade, the phenomenon does have a longer historical background...

The review presented in this book has been written under the sponsorship of the Interuniversitary Consortium "National Institute of Biostructures and Biosystems (INBB)", constituted by 26 Public Italian Universities. INBB is stimulating the research on endocrine disruptors, by encouraging and coordinating joint research projects between its members and those of other Italian public scientific institutions. This book represents one of the results of the meeting "The biological and clinical research on endocrine disruptors: current status and perspectives", held in Rome during 2005 from October 27 to 28 and organized by INBB and ISPESL (Istituto Superiore Prevenzione e Sicurezza del Lavoro)...

These reviews emphasize that many environmental chemicals possess endocrine-disrupting properties, and that exposure to such chemicals can have adverse effects on health and reproduction even at very low concentrations. Great care should be used when attempting to apply these data to other species or real life situations. Indeed only a paucity of information is available on the metabolism and tissue distribution of these chemicals which may vary according to species physiology as well as to levels and duration of exposure. Furthermore, the possible interactions between single contaminants of the complex mixtures present in the environment may induce completely unpredictable effects, due to synergies or reciprocal inhibition effects, suggesting great caution in drawing conclusions. It is hoped that these reviews will serve to stimulate further research on EDs and human health. ... Read more

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This database, available in print and electronic form, provides information on chemical, physical, and toxicological properties of known and suspected environmental endocrine disruptors in a convenient easy-to-use format. Much of the research on EEDs has focused on the effects of these chemicals on wildlife, linking certain compounds to birth defects and abnormal development of immune and reproductive systems. ... Read more

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The book is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of Biologically Based Risk Assessment, as developed form Physiologically-Based Toxicokinetic Models. The analysis of this material is proposed as the novel parameters for developing Biologically Based Models of Carcinogenesis, considered to be more relevant to risk assessment than traditional approaches. This data appears unique in an important and rapidly developing field. ... Read more

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• Timely title assembling the combined knowledge of some of the leading authorities in the field of small fish reproduction - an important topic for risk assessment and registration of chemical, agricultural, and pharmaceutical compounds
• Provides guidance on the microscopic structure of living tissue and evaluation of the reproductive glands of small laboratory fish
• Includes state-of-the-art science along with sufficient anatomical and physiological background for understanding and interpreting test results
• Helps standardize the interpretation of results from aquatic bioassays and field observations, which will also clarify inconsistencies in the current scientific literature

Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file. ... Read more

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Uses Computational Tools to Simulate Endocrine Disruption Phenomena

Endocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributors from industry, academia, and regulatory agencies, this is the first book devoted to using computer tools to better understand and simulate the multifaceted aspects of endocrine disruption in humans and wildlife.

Product Description
In 1941 the Food and Drug Administration approved the use of diethylstilbestrol (DES), the first synthetic chemical to be marketed as an estrogen and one of the first to be identified as a hormone disruptor—a chemical that mimics hormones. Although researchers knew that DES caused cancer and disrupted sexual development, doctors prescribed it for millions of women, initially for menopause and then for miscarriage, while farmers gave cattle the hormone to promote rapid weight gain. Its residues, and those of other chemicals, in the American food supply are changing the internal ecosystems of human, livestock, and wildlife bodies in increasingly troubling ways.In this gripping exploration, Nancy Langston shows how these chemicals have penetrated into every aspect of our bodies and ecosystems, yet the U.S. government has largely failed to regulate them and has skillfully manipulated scientific uncertainty to delay regulation. Personally affected by endocrine disruptors, Langston argues that the FDA needs to institute proper regulation of these commonly produced synthetic chemicals. ... Read more

Customer Reviews (5)

Fabulous book!A definite must read!
An amazing book.Truly a must read....I would right more now, but I can't put it down...;o)Patti Negri

Great Book!
I've just finished reading _Toxic Bodies_ and I have to commend Nancy Langston on a superb and desperately needed new book.Wow!The story (and stories) she tells are staggering and informative and written in an accessible style.This is a landmark study in environmental health and safety.It's also one of the finest combinations of the themes of gender, science, and the environment that I've seen in quite some time - I've already recommended it to colleagues and I'm sure it will find a home in many different environmental studies classrooms.Indeed, I intend to assign it in my Environmental History course in the spring semester.

"Important Information Enclosed"
Having recently completed "Toxic Bodies" I chose to title my thoughts as noted above. Dr. Langston has presented the research and the conclusions about the heavy use of DES in our medical and agricultural systems in a manner that is readable and understandable for persons with lesser scientific backgrounds. She does this in a story like format that leaves one with a sense of urgency about the present and emerging chemicals that effect us in our daily lives. The sense of urgency on a personal level leads one to question a medical care provider about any prescribed medication and to seriously consider any over the counter "drugs or food supplements" one might consume. I would suggest that readers (especially women) share this book with their medical care provider. The sense of urgency on the community level is to comment to law makers related to ongoing issues with chemicals that we are currently being warned about as harmful, especially to children. Great work on this book, Dr. Langston. Thank you for it.
Nancy Moye RN, PHN

Toxic Bodies
Toxic Bodies by Nancy Langston is a cautionary tale indeed -- one that should scare the heck out of any woman of reproductive age.Actually, everyone should read this book, and then contact their government representatives and insist on stricter regulations and overall transarency with regards to synthetic chemicals that enter our bodies through a mariad of ways;food sources, water, medications, and from mother to child.

Apparently, I am one of the lucky ones -- even with a variety of frightening reproductive issues, I was able to bring a healthy baby to term -- but now she, at the age of 18, seems to be tackling some of the same gynecological issues I faced 30 years ago.

Dr. Langston's concise and readable book should encourage all of us to live a more healthy, chemical-free lifestyle.And, to ask the right questions when visiting our doctors. Ladies and gentlemen, its time to take a proactive stance!

Scary; Exciting
Toxic Bodies: Hormone Disruptors and the Legacy of DES by Nancy Langston is a real-life mystery story that captures your attention and could keep you awake at night wondering.....
It's very immediately topical, especially given the current arguments, in several states. about banning the chemical bisphenol-A, BPA, from a variety of products including baby bottles and sippy-cups.
Toxic Bodies should get the attention of state and federal legislators as well as the general public, if only to encourage a public dialogue on the problems, and work toward awareness and a possible solution
... Read more

Product Description
Endocrine Disrupting Chemicals: From Basic Research to Clinical Practice is the first book that provides comprehensive coverage of the three most important themes in the field of EDC research: the basic biology of EDCs, particularly their effects on reproductive systems; EDC effects on humans and wildlife, including biomedical considerations; and potential interventions and practical advice for dealing with the problem of EDCs. This book presents a translational approach to EDC research, spanning both basic biology and clinical applications, and provides a critical link between the laboratory and the physicians’ office. Scientists and physicians engaged in EDC studies or practice will find that this volume offers insight across all areas of EDC research, including clarifying the mechanisms for EDC effects, understanding the adverse affects of EDCs on humans and wildlife, and offering solutions to the problems created by exposures to EDCs. ... Read more

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This digital document is an article from OB GYN News, published by International Medical News Group on November 1, 2009. The length of the article is 945 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Endocrine disruptors: a top research priority.(OBSTETRICS)
Author: Jeff Evans
Publication: OB GYN News (Magazine/Journal)
Date: November 1, 2009
Publisher: International Medical News Group
Volume: 44Issue: 13Page: 18(1)

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Product Description
The field of endocrine disruption or endocrine active compounds (EACs), which is just emerging and still controversial, is comprehensively covered by leading experts in Volume 3, Subvolumes L (Part I) and M (the present volume, Part II). The major classes of endocrine active chemicals are discussed, as well as methods for their detection and their association with health disturbances in humans and wildlife. The etiology of several of the human diseases associated with endocrine disruptors, e.g. breast and prostate cancer, decreased fertility and malformations, is still poorly understood, and the current state of knowledge is presented. Since hormonally active agents appear to have the potential of both adverse and beneficial effects, the evidence of health benefits associated with endocrine active compounds in humans is also presented. Basic chapters on the mode of action of EACs and on the etiology of the associated diseases facilitate the understanding of this complex subject for non-medical readers. ... Read more

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This digital document is an article from Environmental Health Perspectives, published by National Institute of Environmental Health Sciences on April 1, 2003. The length of the article is 7910 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Cancer and developmental exposure to endocrine disruptors. (Research).
Author: Linda S. Birnbaum
Publication: Environmental Health Perspectives (Refereed)
Date: April 1, 2003
Publisher: National Institute of Environmental Health Sciences
Volume: 111Issue: 4Page: 389(6)

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This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on January 1, 2007. The length of the article is 838 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: Emerging research on endocrine disruptors.(DIRECTOR'S PERSPECTIVE)
Author: David A. Schwartz
Publication: Environmental Health Perspectives (Magazine/Journal)
Date: January 1, 2007
Publisher: Thomson Gale
Volume: 115Issue: 1Page: A13(1)

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This digital document is an article from Environmental Health Perspectives, published by Thomson Gale on June 1, 2006. The length of the article is 473 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

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Title: PCBs are endocrine disruptors: mixture affects reproductive development in female mice.(Science Selections)
Author: Victoria McGovern
Publication: Environmental Health Perspectives (Magazine/Journal)
Date: June 1, 2006
Publisher: Thomson Gale
Volume: 114Issue: 6Page: A368(2)

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This digital document is an article from Canadian Chemical News, published by Chemical Institute of Canada on April 1, 1997. The length of the article is 1735 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Endocrine disruptors: beyond the headlines.
Author: J.E. Heinze
Publication: Canadian Chemical News (Magazine/Journal)
Date: April 1, 1997
Publisher: Chemical Institute of Canada
Volume: v49Issue: n4Page: p17(2)

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