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Customer Reviews (1)

People with RA need this book
I have several books on Rheumatoid Arthritis, but this is by far the best of them.Everything you need to know is here.The only thing is doesn't do is keep up with new medicines. ... Read more

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If you were diagnosed with a crippling chronic illness in the prime of your life and everything that was considered normal vanished whom would you turn to? The person you would turn to is me, Linda D’Angelo because I have been suffering from rheumatoid arthritis for over ten years.The book you would purchase is my book “Failure Is Not An Option, Thriving with Rheumatoid Arthritis” because my book is the story of a woman who understands her illness and found the courage and strength of character to step up, face her fears and ascertain her desired outcome, thriving with rheumatoid arthritis. Whether you are newly diagnosed with this illness or a veteran wondering whether you will ever experience a normal life again, my advice to you is “fight” and “fight hard” because your quality of life and the lives of those close to you are in jeopardy.Life presents you with a number of challenges, these challenges can sometimes be unexpected, undeserved and beyond your control.Therefore it is important to remember that life is never about the challenge itself, it is about you, and how you choose to handle the challenge. ... Read more

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Courageous
There is an oft-quoted phrase by Aeschylus most famously used by Robert Kennedy in an eulogy for Dr. Martin Luther King Jr. "In our sleep, pain which cannot forget falls drop by drop upon the heart until, in our own despair, against our will, comes wisdom through the awful grace of God". Linda D'angelo endured her pain with great dignity and faith, and at the end she came out wiser and stronger.

This book gives a glimpse of her experience as a patient of rheumatoid arthritis (RA). The onset of this ailment almost took away the self-respect of a strong and independent woman. Linda's amazing inner strength and common sense, along with some luck in the form of an experimental drug brought her back to an active, normal and enjoyable life. This book is not only the tale of personal triumph over suffering, but also a sourcebook for patients suffering from RA. The book is well researched and the prose is fluid. ... Read more

Product Description
Rheumatoid arthritis is a crippling disease, affecting individuals in the prime of their life. This disease is emerging as a paradigm for complex autoimmune syndromes in which multiple genetic risk determinants in combination with non-inherited factors predispose individuals to generate chronically persistent and destructive immune responses. As a consequence of exploring the immunopathology of rheumatoid arthritis, biologic response modifiers have been introduced as a fundamental new therapeutic strategy for this clinically challenging disease. This book, the third volume of the new series "Current Directions in Autoimmunity", is the first one to exclusively focus on one disease. Written by experts in genetics and immunobiology, the articles reflect the complexity and multiple facets of the disease process but also show their convergence to a better understanding of pathogenetic mechanisms and the evolving clinical applications. ... Read more

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This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone! ... Read more

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This digital document is an article from Internal Medicine News, published by Thomson Gale on October 15, 2006. The length of the article is 727 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Abatacept slows rheumatoid arthritis damage.(Rheumatology)
Author: Nancy Walsh
Publication: Internal Medicine News (Magazine/Journal)
Date: October 15, 2006
Publisher: Thomson Gale
Volume: 39Issue: 20Page: 37(1)

Distributed by Thomson Gale ... Read more

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Many advances have occurred in the last 5 years especiallyin understanding genetic susceptibility factors, the role ofimmune response in chronicarthritis and the relationshipbetween cellular processes that underlie inflammation andtissue damage. All these are dealt with in depth intheindividual contributions.Genetics studies included illustrate howstudies of HLAgenes and genes controlling the autoantibody repertoiremaybe involved. Environmental factors are believed to beimportant and studies both in humans and in experimentalmodels on the role of viral andbacterial agents arecovered. The fascinating relationship betweenmicrobes,dysregulated immune responses and oncogenes are alsoexamined.Since autoimmunity is the key aspect of theimmunologicalresponse in rheumatoid arthritis, the role of antigensisre-examined as is the part played by immune T and B cells.New areas of clinical application of basic science is wellpresented in this book, forexample, in examining howmarkers of cartilage destruction may become important inmonitoring disease activity. A chapter reviewing possiblefuture novel therapies is included. ... Read more

Product Description
This scarce antiquarian book is a selection from Kessinger Publishing's Legacy Reprint Series. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment to protecting, preserving, and promoting the world's literature. Kessinger Publishing is the place to find hundreds of thousands of rare and hard-to-find books with something of interest for everyone! ... Read more

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Univ. of California, San Diego. Multiauthored textbook discusses the scientific basis of the pathogenesis of RA, and the rationale for the treatment of the disease. Describes latest advances and relates this knowledge to the application of a rational therapeutic approach to its management. For clinicians and researchers. DNLM: Arthritis, Rheumatoid--therapy. ... Read more

Customer Reviews (2)

Very interesting and detailled book
This book gives a very detailled description of the joint pathologies, looks at different causes, genetic, bacterial or viral.The section on arthritic pain is a little short, even though pain is one of the most important symptoms of the disease. But some of the world's authorities in the field have contributed to this book, and it is very interesting to have such a group putting their knowledge together.

a new frontier in rheumatoid arthritis
This book is the demonstration of the exciting development in rheumatology for what concerns the knowledge of pathogenesisand the treatment of Rheumatoid Arthritis. Thelist of authors is a Who is Who's in rheumatology. The book begins with an introductory part on etiology that contains the fundamental chapter on the role that the polygenic nature of rheumatoid arthritisplays in the disease pathogenesis. In this chapter, the problem of HLA association with RA is well presented and the problem of candidate genes analysed for the first time. The chapter on infectious agents is interesting and presents not only viruses but also a part devoted tobacteria (proteus, klebsiella, chlamidia, borrelia, and others) as potential causative agents of the disease.In the section on mechanisms of inflammation, each chapteris thorough and comprehensive and offers a deepening in the understading of the disease pathogenesis. In fact, the whole disease pathogenesis is dissected by the role that each cell (lymphocytes, macrophages, neutrophils, synoviocytes), each mechanism (adhesion and homing, apoptosis) and the cytokine network play. This part is enriched also by a chapter on pain mechansimsthat explores exhaustively the different aspects of pain generation and the contribution of the peripheral nervous system to the generation of inflammation.Indeed, this section is closed by a chapter that summarises the interaction of all the single factors analysed one-by-one in the previous chapters and gives a general overview on the mechanisms of joint destruction and the consequent therapeutic implications.The section on clinical aspects is comprehensive and enriched by the chapters on imaging and on the utility of molecular markers for the assessment of cartilage damage. However, the feeling of the reader is that, in a further edition of the book , the number of chapters concerning the description of and the approach to the clinical features of thedisease should be more numerous. The book might benefit from the evaluation ofthe problems of the early diagnosis and of the progression of the disease to the late phase, and from a detailed presentation of the differential diagnosis as well as the analysis in detail of the joint and organ involvement. In fact, the limitation of the purely clinical section strongly reduces the attraction of the book for practicioners. The sections on drugs is largely exhaustive and analyses not only glucocorticoids and NSAIDs but all the DMARDs (gold salts, antimalarials, sulfasalazine, methotrexate, and others). This part of the book contains also a useful chapter on intrarticular therapy and a chapter on the new techniques ofcombining different DMARDs in thetreatment of RA. This part iscomplemented by an excellent section on the surgical treatment of different joints affected by the disease and by practically useful chapters on diet, patient education and psychological and social aspects of rheumatoid arthritis. Probably, the most interesting part for the rheumatologistis the last section of the book that presents for the first time a new and focused way in approaching the management of the disease. All possible compounds thatblock the effects ofproinflammatory cytokines TNF alfa, IL-1, IL-6, IL-8) or that enhance theaction of antinflammatory cytokines (IL-4, IL-10, IL-13) are accurately analysed. This section is also enriched by chapters devoted to new treatments targeting the cells (lymphocytes and macrophages) responsible for the disease pathogenesis,to the factors (matrix metalloproteinase) involved in cartilage breakdown, and to the novel inhibitors of transcription factors and their upstream activators that block signal transduction and gene transcription in inflammatory cells. Indeed, the new chapter on clinical trials provides a helpful and enjoyable reading forany physicianthat needs to understand the modality and the tools with which the efficacy of new therapies in rheumatoid arthritis is tested. This book demonstrates the enormous achievement in the knowledge of pathogenesis that has been transformed in practice in targeted treatments. For this reason it gives to physicians an intellectual and modern pathway of looking at rheumatoid arthritis. The book may be useful for practicing physicians, advanced medical students, andfellows. More likely, the book may be used frequently by specialists in rheumatologyto deepen their knowledge into the pathogenesis of the disease as well as it may assist them in the choice of the strategy and in the tailoring of the treatment in rheumatoid arthritis patients. ... Read more

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Northwestern University, Chicago, IL.Text on the principles underlying rehabilitation of those with RA, for physicians. Emphasis on concepts rather than protocols. 21 U.S. contributors. DNLM: Arthritis, Rheumatoid rehabilitation. ... Read more