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G. Landes). Quadrant Healthcare, Cambridge, U.K.Research for clinicians and investigators. 10 contributors, 1 U.S. DNLM: Artherosclerosis--physiopathology. ... Read more

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This work offers a detailed single reference on the entire spectrum of basic and clinical studies of heparin and its effect on atherosclerosis. The book presents innovative aspects of heparin's use in both the prevention of atherosclerosis and for intervention with thrombotic complications. In addition to research studies in animals and humans, the book includes case histories, illustrates indications for heparin's prophylactic use in coronary atherosclerotic disease and compares heparin to other therapeutic modalities. The volume also covers adverse reactions to heparin and new data on lowering elevated fibrinogen levels with low-dose heparin and makes suggestions for future research. ... Read more

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North Glasgow Univ. Hospitals Trust, UK. Annual discusses the latest ideas in research and clinical practice in this field of study. Covers the impact of lipid-lowering drugs on rheology, the effects of statin therapy on HDL, new strategies for lipid management, and the use of functional foods and drugs in the management of acute coronary syndrome. Previous edition: c2001. ... Read more

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This monograph on recent progress in atherosclerosis research presents state-of-the art morphological investigations on the cells and their metabolism in the atherosclerotic plaque in situ. The spectrum of methods includes immunohistologic and immunoelectron microscopic investigations on the localization of apolipoproteins in the cells of the arterial intima, presenting new data on the lipoprotein metabolism in plaque. The collagen metabolism is analysed by in situ hybridization techniques for demonstrating the synthesis of different collagen types on the messenger RNA level. Concentrating on in situ investigations with sophisticated morpholocial methods, the widespread discussion on atherogenesis is focused on the arterial wall and its morphological alterations. As morphology remains the basis for understanding the pathogenesis of disease, the results presented here could be of interest not only to pathologists, but also to clinicians and researchers working in the field of biology of atherosclerosis. ... Read more

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A number of epidemiological and experimental animal studies have shown that some kind of an oxidative process is involved in atherosclerosis. Recent evidence suggests that the oxidation of low-density lipoprotein (LDL) may render it more atherogenic. The oxidized LDL exhibits multiple pro-atherogenic properties. This text discusses the mechanisms of the formation of oxidized LDL and its atherogenic effects on cells of the arterial. The potential role of antioxididants in preventing heart disease is also critically addressed. ... Read more

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The discovery that plasma cholesterol and lipoproteinconcentrations are major predictors of risk has been one of the mostimportant factors behind the dramatic and steady reduction in deathsdue to coronary heart disease seen over the last 30 years. However,although the significance of lipids is now well understood, we haveyet to identify the ideal way to protect patients, particularly thosewith inherited lipoprotein disorders, against atherosclerosis. New work described in this book sheds light on that important issue,especially on the role of the A apoproteins in HDL. For example,experimental gene transfer studies indicating that apoproteinA--1 may counteract the hyperlipidaemia and atherosclerosisfound in apo--E deficiency suggest that we may soon be able tooffer prophylaxis to patients whose risk of heart disease is greatlyincreased by a genetically--determined shortage of HDL. The significance of a greater understanding of lipoproteins may evenextend the cardiovascular field, as other research presented in thisbook illustrates; there is a growing interest, for example, in theireffects on nervous tissue. Nevertheless, the most important goalremains the prevention of heart disease and the prospect of universalprotection against premature atherosclerosis has never been brighter. ... Read more

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Lipoprotein disorders are among the most common metabolic derangements encountered in industrialised countries. Figures for the United States of America, for example, reveal that more than half of the adult population have too high plasma cholesterol levels. It is not surprising that ischaemic heart disease remains the commonest cause of death in the western world. This volume focuses on the origin of the problem by exploring the factors which govern the structure and metabolism of human plasma lipoproteins and those which regulate lipoprotein interaction with the developing atherosclerotic lesion. Secondly, recent advances in the pharmaceutical industry have led to the development of powerful and effective new lipid lowering drugs. The practising physician needs to know when to use these agents and what to expect of them. This topic is examined in some detail to provide a basis for rational lipid lowering pharmacotherapy if dietary intervention fails. The implementation of effective intervention programs offers the prospect of reducing the impact of heart disease and improving the quality and expectation of life in the community. ... Read more

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A presentation of lipid disorders and their implication in heart disease. Approximately half the text includes discussion of various therapeutic options, with up-to-date pharmacological analysis. ... Read more