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This volume examines the application of NMR techniques to molecular biology, including gene cloning and expression, site- specific mutagenesis, and biosynthetic isotopic labelling. It describes the broad-ranging applications of NMR techniques to the elucidation of structures at atomic resolution for moderately large systems. Investigators from a variety of disciplines cover the analysis of conformation, dynamics and interactions for a variety of molecules, including DNA, RNA, carbohydrates, peptides and proteins. Throughout the text, the contributors demonstrate the success of multi-dimensional NMR studies of biopolymers in solution. The book also examines possible NMR approaches for investigating systems where the molecule of interest does not reorient rapidly in solution. These systems possess molecules in the crystalline or hydrated solid state, part of supramolecular structures in solution, or are simply too large to reorient. ... Read more

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This book teaches the analyst why it is advantageous to obtain vibrational data under different physical phases.Molecular vibrations are affected by change in physical phase, and knowledge of how certain molecular vibrations are affected by change in the chemical environment improves the analyst's ability to solve complex chemical problems.

This book is invaluable for students and scientists engaged in analytical and organic chemistry, since application of IR and Raman spectroscopy is essential in identifying and verifying molecular structure.

This reference provides analysts with information that enables them to acquire the maximum amount of information when sampling molecular vibrations via IR and Raman spectroscopy.


Key Features
* Explains why it is advantageous to obtain vibrational data under different physical phases
* Compiles many vibrational studies into a single compendium
* Lists group frequencies in different physical phases
* Reveals that some group frequencies are more affected than others by changes in the physical phase
* Demonstrates that in-phase and out-of-phase vibrations of the same functional group are not equally affected
* Describes how solute-solvent complexes differ with changes in the solvent system
* Shows that the amount of Fermi resonance between a fundamental vibration and a combination or overtone is altered with change of physical phase
* Written by an internationally recognized expert ... Read more

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Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry.

Product Description
Nuclear Magnetic Resonance Spectroscopy is the only "tool" available for the determination of high-resolution biological molecule structure in solution. This volume includes methods for expeditiously analyzing the vast amount of data produced by the new 3D and 4D NMR techniques and for generating structures from the data and for assessing the quality of those structures. Application to various classes of important proteins and protein-ligand complexes illustrate uses of the methodology presented. Examination of techniques to explore the dynamic nature of proteins complete the volume. ... Read more

Product Description

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry.

Product Description
The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 250 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. ... Read more

Product Description
This volume examines and describes the role of NMR insupporting and extending modern technology. It is aimed mainly at thequestion, `What is NMR doing to assist modern technology?' and to somedegree points to what NMR could be doing in industry. Chapterswritten by some of the international leaders in the development andapplications of NMR range from introductory principles to advancedapplications that describe areas currently relevant to modernindustrial activity, or which could be. The introductory coverageincludes a brief description of the fundamental basis of NMR phenomenafor solids and liquids, and detailed descriptions of line-broadeninginteractions and line-narrowing techniques for solid samples.Applications are described for biological and synthetic polymers,coal, silicas, zeolites, glasses, ceramics, composites, and catalysts,and include 2-D approaches and process-control applications. Theintended level is that of a first or second year graduate student inchemistry, or a practicing scientist or engineer in industry. ... Read more