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Connective tissue diseases demand study because of theirfrequency, morbidity and mortality. They present intriguing challengesin the fields of diagnosis, management and research. Their range hasnow expanded enormously so that no individual can master the wholesubject, particularly as this relates to their immunologicalbasis.Immunology of Connective Tissue Diseases has been written byexperts who are either clinical or basic scientists. The book presentsup-to-date reviews of the immunological basis of connective tissuediseases as it impacts on diagnosis, pathogenetic concepts, diseasemonitoring and management. The book is aimed at physicians interested in understanding theimmunological basis of these diseases, and at immunologists who areeither entering this field for the first time and would like to have aconvenient state-of-the-art account of its status, or who areresearching in one area and would like to acquaint themselves with thedevelopments which have taken place in others. ... Read more

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Our understanding of inflammation has increased rapidly inrecent years, due in large part to the impact of molecular biology andgene identification and cloning. This book brings together ideas froma number of different biochemical disciplines which are frequently notintegrated.
The first chapter gives a visual overview of the subject; theremaining chapters are organized into three themes: the affectormolecules, the regulatory components and the processes of inflammationitself.
This book is essential reading for the busy physician or pathologistwho wants to be up-to-date with the latest developments in immunologyas they affect the diagnosis and treatment of many conditions.
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Drs. Glen Furuta and Dan Atkins have assembled an in-depth look at Eosinophilic Gastrointestinal Diseases as related to allergy with topics such as "Basic pathogenetic mechanisms of Eosinophilic Esophagitis", "Nutritional management of patients with food allergies and EGIDs", "Chemotactic factors role in EGIDs", "Biomarkers associated with allergic diseases", "Association of other allergic diseases with EGIDs" and much more! ... Read more

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Dr Werner Pichler has developed an issue of top specialists discussing Drug Hypersensitvity. Topics include: "Approach to the patient with drug allergy," "Perioperative anaphylaxis," "Basophil activation test in drug allergy," "In vitro tests," "Desensitizations," and more! ... Read more

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This proceedings is a compilation of the main papers presented at the above mentioned conference. Over 500 scientists attended the meeting. The intention was to cover the area of Respiratory Allergy which is on the borderline between different specialities that are rapidly developing, such as basic immunology, clinical medicine. The papers contained herein are up-to-date, presented in a concise format and allow people interested in this field the opportunity to quickly cover several aspects of this rapidly moving discipline. ... Read more

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These new editions of the "MRCP 1 Pocket Book" series make revision for the Part 1 examination active and effective. Each of the three pocket books features questions and answers providing essential practice for the MRCP Part 1 exam. They are presented in a clear layout with each book covering four or more subjects focusing on popular exam topics. The questions have excellent clinical scenarios with expanded explanations to boost your knowledge. Each book contains 'best of five' questions covering: Book 1: Cardiology, Hematology, Respiratory Medicine, Rheumatology, Immunology; Book 2: Basic Sciences, Infectious Diseases, Neurology, Psychiatry; and, Book 3: Clinical Pharmacology, Endocrinology, Gastroenterology, and Nephrology. This portable pocket book series will enable you to: pinpoint and gain practice in your weaker areas; structure your revision in an effective way; and, revise on-the-go. ... Read more

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Antibodies are crucial to the fine specificity of the immunesystem. An effective functioning of these molecules requiresinteraction with immune cells. Receptors for antibodies, Fc receptors,provide this critical link between the humoral and cellular branchesof the immune system. This book presents a comprehensive overview ofthe different Fc receptors currently recognized. The first part of thebook contains state-of-the-art overviews on the biological role ofFcR. The latest information on FcR heterogeneity, FcR physiology,FcR-ligand recognition, their crucial coordinating role in immunity,interactions with other immunoreceptors, and the role of FcR inimmunoglobulin transport and catabolism are discussed. The clinicalimportance of FcR is developed in the second part of the book. Thewell-recognized roles of FcR in allergy, inflammation, infectiousdiseases, autoimmune disorders, and immunotherapeutic importance arereviewed. The information in this book is easily accessible and shouldbe helpful for researchers and clinical specialists as a convenientoverview of the field, as well as a comprehensive introduction forstudents starting in this area of research. ... Read more

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This outstanding resource offers comprehensive presentations of the latest basic knowledge and the most advanced research on neuropeptides of the respiratory tract–covering the structure, receptors, molecular biology, and function of each important neuropeptide and examining how they relate to disease.Demonstrates the utility of immunohistochemistry, autoradiography, molecular biology, smooth muscle contraction, and glandular secretion for the study of neural function both in vitro and in vivo!Separating the airways into upper and lower areas to allow comparisons between the nasal and pulmonary systems, Neuropeptides in Respiratory Medicine.provides detailed chapters on vasoactive intestinal peptide, neuropeptide Y, sensory neuropeptides, and nitric oxidediscusses peptide antagonists and metabolic pathways, offering insight into the regulation of neuropeptide actionsdescribes the interaction of neuropeptides with cancer, rhinitis, asthma, chronic bronchitis, cystic fibrosis, and immunityoutlines the hypothesis that damage to neutral endopeptidase facilitates respiratory inflammationdelineates controversies in the roles of sensory nerve neurogenic inflammation and sensory nerve neurotransmittersexplains the postulated roles of known neurotransmittersand much more! ... Read more

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Transfusion medicine provides an excellent bridge connectingthe healthy community donors with the patient's needs at the bedside;the dominant philosophy has been on patient care and science, but itis now realised that blood banks manufacture increasing amounts ofblood components to administer to patients -- a role analogous tomanufacturing functions. The concept of Good Manufacturing Practice(GMP) is therefore relatively new. While quality has always beenimportant, the impact of GMP, Total Quality Management (TQM) andQuality Assurance (QA) will be profound. As the regulatory agencies,like the FDA in the U.S.A. and the EEC Commission in Europe, increasetheir enforcement activities, doctors, technical experts and managerswill have to face many issues of quality assurance includingdocumentation, validation, audit system, regulatory laws, licensing,teaching and training of staff and their job descriptions, standards,processing facilities, procedure validations, automation, recordkeeping, internal and external quality control of products and theirrelease. The expansion of this philosophy to include Good ClinicalPractice (GCP) is an even greater challenge demanding consensustherapy protocols and quality management of transfusion throughauditing by the hospital transfusion committees. Such comprehensiveplans will profoundly affect the financial and organisationalstructure of blood transfusion in the future. ... Read more